Yes, I did upgrade from 0.7.3

I rechecked the settings, and now it takes about 6 minutes to open the mysql pro  panel with IE.

Firefox takes about 30 minutes

Suggestions:   Places to check?

Yes, I did not do mysql backend special & dovecot options, which I did do on 2/28

Dovecot options done
Add INDEXes for Amavisd database was already done
[Debian and Ubuntu special] Assign Apache daemon user to group "adm"  was already done
OpenLDAP backend special - not done - n/a
MySQL backend special  done

Do I need to reboot the server?  or anything else Apache?

Update: 3/13/2012
Seems to be getting worse, back up to 15 minutes in IE

maddr        ~160,271 InnoDB utf8_general_ci 58.3 MiB -
mailaddr        0 MyISAM utf8_general_ci 2.0 KiB -
msgrcpt        ~306,258 InnoDB utf8_general_ci 80.6 MiB -
msgs        ~695,309 InnoDB utf8_general_ci 539.7 MiB -
policy        0 MyISAM utf8_general_ci 1.0 KiB -
quarantine        0 InnoDB utf8_general_ci 32.0 KiB -
users        0 MyISAM utf8_general_ci 2.0 KiB -
wblist        0 MyISAM utf8_general_ci 1.0 KiB -
8 table(s)  Sum ~1,161,838 MyISAM utf8_general_ci 678.6 MiB 0 B

1,161,838

Hmm, so many records in these two tables.

You can find below settings in libs/settings.py under iRedAdmin-Pro-MySQL:

###################################
# Amavisd related settings.
#

# Automatically remove SQL records of sent/received mails in Amavisd database
# when viewing sent/received mails. Only one time in each login session.
# Default is 90 days. Set to 0 to keep them forever.
AMAVISD_REMOVE_MAILLOG_IN_DAYS = 30

# Automatically remove SQL records of quarantined mails which older than
# specified days when list quarantined mails. Only one time in each login
# session.
# Since quarantined mails may take much disk space, it's better to release
# or remove them as soon as possible.
# Default is 30 days. Set to 0 to keep them forever.
AMAVISD_REMOVE_QUARANTINED_IN_DAYS = 7

If you don't need to store them for a long time, please try to reduce these two settings. For example, set 'AMAVISD_REMOVE_MAILLOG_IN_DAYS = 7' (one week). Then each time you login to iRedAdmin-Pro and access "System -> Sent Mails" or "System -> Received Mails", old records will be deleted automatically.

Another way is setting up cronjob to delete old records. Reference: http://www.iredmail.org/forum/post12114.html#p12114

I don't understand how to put this into a cron job?

how does it know how to connect mysql?

================
// First one, used to delete quarantined mails which older than 7 days.
// Change "7 DAY" to whatever you want, e.g. 10, means delete mails older than 10 days.

DELETE FROM msgs WHERE content IN ('S', 's', 'V', 'Y') AND quar_type = 'Q' AND time_num < UNIX_TIMESTAMP(DATE_SUB(NOW(), INTERVAL 7 DAY))

// Delete old data in table msgs and msgrcpt.

DELETE msgrcpt.* FROM msgrcpt INNER JOIN msgs ON msgrcpt.mail_id=msgs.mail_id WHERE msgs.content IN ('U', 'M', 'H', 'O', 'C') AND msgs.time_num < UNIX_TIMESTAMP(DATE_SUB(NOW(), INTERVAL 7 DAY))

Still so many records in table 'msgs'.

Not exactly.
Refer to Amavisd official doc for more details: http://www.amavis.org/README.sql-mysql.txt