shure:

<type 'exceptions.TypeError'> at /profile/domain/general/DOMAIN.XY
__init__() should return None, not 'tuple'
Python     /usr/share/apache2/iredadmin/controllers/mysql/domain.py in GET, line 126
Web     GET https://mail.DOMAIN.ZZ/iredadmin/profil … /DOMAIN.XY
Traceback (innermost first)

    /usr/share/apache2/iredadmin/controllers/mysql/domain.py in GET
        throttleLib = throttle.Throttle() ...
    ? Local vars
    /usr/share/apache2/iredadmin/controllers/decorators.py in proxyfunc
        return func(self, *args, **kw) ...
    ? Local vars
    /usr/lib/python2.7/dist-packages/web/application.py in handle_class
        return tocall(*args) ...
    ? Local vars
    /usr/lib/python2.7/dist-packages/web/application.py in _delegate
        return handle_class(cls) ...
    ? Local vars
    /usr/lib/python2.7/dist-packages/web/application.py in handle
        return self._delegate(fn, self.fvars, args) ...
    ? Local vars
    /usr/lib/python2.7/dist-packages/web/application.py in process
        return self.handle() ...
    ? Local vars

Request information
INPUT

No data.
COOKIES
Variable    Value
PHPSESSID   
'2as9chf2nchvghelts49i11v94'
composesplitterv   
'248'
iRedAdmin-Pro   
'ef5631414af4553ddbebae8f6490e25b2fa0b819'
identviewsplitter   
'266'
language   
'de'
mailviewsplitter   
'310'
mailviewsplitterv   
'226'
managesievesplitter1   
'156'
managesievesplitter2   
'186'
prefviewsplitter   
'266'
roundcube_sessauth   
'S6a3689381655eb20494593aa40550250f9332eea'
roundcube_sessid   
'8b4b6u740e6hjr95st6pmda794'
META
Variable    Value
app_stack   
[<web.application.application instance at 0x7f15c12e6170>]
fullpath   
u'/profile/domain/general/DOMAIN.XY'
headers   
[]
home   
u'https://mail.DOMAIN.ZZ/iredadmin'
homedomain   
u'https://mail.DOMAIN.ZZ'
homepath   
u'/iredadmin'
host   
u'mail.DOMAIN.ZZ'
ip   
u'46.140.133.2'
lang   
'en_US'
method   
u'GET'
output   
u''
path   
u'/profile/domain/general/DOMAIN.XY'
protocol   
u'https'
query   
u''
realhome   
u'https://mail.DOMAIN.ZZ/iredadmin'
status   
'200 OK'
ENVIRONMENT
Variable    Value
DOCUMENT_ROOT   
'/var/www'
GATEWAY_INTERFACE   
'CGI/1.1'
HTTPS   
'1'
HTTP_ACCEPT   
'text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8'
HTTP_ACCEPT_ENCODING   
'gzip, deflate'
HTTP_ACCEPT_LANGUAGE   
'de-de,de;q=0.8,en-us;q=0.5,en;q=0.3'
HTTP_CACHE_CONTROL   
'max-age=0'
HTTP_CONNECTION   
'keep-alive'
HTTP_COOKIE   
'iRedAdmin-Pro=ef5631414af4553ddbebae8f6490e25b2fa0b819; mailviewsplitterv=226; prefviewsplitter=266; identviewsplitter=266; language=de; composesplitterv=248; mailviewsplitter=310; managesievesplitter1=156; managesievesplitter2=186; PHPSESSID=2as9chf2nchvghelts49i11v94; roundcube_sessid=8b4b6u740e6hjr95st6pmda794; roundcube_sessauth=S6a3689381655eb20494593aa40550250f9332eea'
HTTP_DNT   
'1'
HTTP_HOST   
'mail.DOMAIN.ZZ'
HTTP_REFERER   
'https://mail.DOMAIN.ZZ/iredadmin/domains'
HTTP_USER_AGENT   
'Mozilla/5.0 (Macintosh; Intel Mac OS X 10.9; rv:24.0) Gecko/20100101 Firefox/24.0'
PATH_INFO   
'/profile/domain/general/DOMAIN.XY'
PATH_TRANSLATED   
'/var/www/profile/domain/general/DOMAIN.XY'
QUERY_STRING   
''
REMOTE_ADDR   
'46.140.133.2'
REMOTE_PORT   
'62995'
REQUEST_METHOD   
'GET'
REQUEST_URI   
'/iredadmin/profile/domain/general/DOMAIN.XY'
SCRIPT_FILENAME   
'/usr/share/apache2/iredadmin/iredadmin.py'
SCRIPT_NAME   
'/iredadmin'
SERVER_ADDR   
'192.168.164.31'
SERVER_ADMIN   
'iasdadsadasdasdasdad'
SERVER_NAME   
'mail.DOMAIN.ZZ'
SERVER_PORT   
'443'
SERVER_PROTOCOL   
'HTTP/1.1'
SERVER_SIGNATURE   
'<address>Apache Server at mail.DOMAIN.ZZ Port 443</address>\n'
SERVER_SOFTWARE   
'Apache'
SSL_TLS_SNI   
'mail.DOMAIN.ZZ'
mod_wsgi.application_group   
'*.DOMAIN.ZZ|/iredadmin'
mod_wsgi.callable_object   
'application'
mod_wsgi.handler_script   
''
mod_wsgi.input_chunked   
'0'
mod_wsgi.listener_host   
''
mod_wsgi.listener_port   
'443'
mod_wsgi.process_group   
'iredadmin'
mod_wsgi.request_handler   
'wsgi-script'
mod_wsgi.script_reloading   
'1'
mod_wsgi.version   
(3, 3)
wsgi.errors   
<mod_wsgi.Log object at 0x7f15a8a5f030>
wsgi.file_wrapper   
<built-in method file_wrapper of mod_wsgi.Adapter object at 0x7f15a7de6cd8>
wsgi.input   
<mod_wsgi.Input object at 0x7f15a8a5f0b0>
wsgi.multiprocess   
False
wsgi.multithread   
True
wsgi.run_once   
False
wsgi.url_scheme   
'https'
wsgi.version   
(1, 1)

You're seeing this error because you have web.config.debug set to True. Set that to False if you don't want to see this.

it sounds realy strange but now it works on the same machine...i have don nothing.
is there some where a cache of the application that have to be cleaned?

have it again, try to find something in the apache error log.

Sorry about this trouble.

Please disable Policyd integration in iRedAdmin config file /usr/share/apache2/iredadmin/settings.ini (set 'enabled = False'), then restart Apache service and try again.

[policyd]
enabled = False

Debian ships Cluebringer (a.k.a. Policyd-2) instead of Policyd-1.8, but iRedAdmin-Pro doesn't support Cluebringer yet, so you have to disable it temporary.

Upcoming release of iRedAdmin-Pro supports Cluebringer, and it will be available in about 2-3 weeks. Please be patient.