I'm developing a WordPress multisite installation that eventually will have a few hundred sites in the network, with domain-mapping (so users can have www.foo.com instead of foo.multisite.com).  I know how to get this working.

I'm trying to figure out the best email solution and I came across iredmail very quickly, as it seems to have an excellent reputation.  I just want to know if it is possible to configure this solution:

1.  Single installation of iredmail on Amazon AWS EC2 cloud instance.

2.  Use Amazon SES as the mail transport system (I apologize if I am not using the correct terminology).

3.  My users will be able to have personal emails with their own domain:  jim@foo1.com, bill@foo2.com, tom@foo3.com -- etc.

4.  Integrate with a web email client like roundcube, so users can visit URL:  www.foo1.com/webmail -- and access their own email, be able to change email password and other profile settings.

I am a developer but I do not want to have to write a lot of glue code to make this work - is this a typical/standard use-case and should I expect to be able to do the installation and easily configure this - or will this be very difficult?

Thank you for any advice or insight you can give me.