Hi Kris
I don't know your situation (specially not legaly) but I'd try to block and ban executable attachments and use additional signatures for clamav.
To ban some executable files (by extension) edit your amavis configuration (in debian&ubuntu /etc/amavis/conf.d/50-user). If not yet present add $banned_filename_re, like this:
$banned_filename_re = new_RE(
## block banned file(1) types, rudimentary
qr'^\.(exe-ms|dll)$',
qr'^\.(exe|lha|cab|dll)$',
qr'.\.(pif|scr)$'i,
# block these MIME types
qr'^application/x-msdownload$'i,
qr'^application/x-msdos-program$'i,
qr'^application/hta$'i,
# block certain double extensions in filenames
qr'\.[^./]*[A-Za-z][^./]*\.\s*(exe|vbs|pif|scr|bat|cmd|com|cpl|dll)[.\s]*$'i,
# banned ext - long
qr'.\.(ade|adp|app|bas|bat|chm|cmd|com|cpl|crt|emf|exe|fxp|grp|hlp|hta|
ins|isp|js|jse|lnk|mda|mdb|mde|mdw|mdt|mdz|msc|msi|msp|mst|
ops|pcd|pif|prg|reg|scr|sct|shb|shs|vb|vbe|vbs|
wmf|wsc|wsf|wsh|bin|drv|ocx|ovl|ani|cur|ico|
ps1|psd1|psm1|ps1xml|clixml|psc1|pssc|
jar|lib|sys|vxd)$'ix,
# banned extension - WinZip vulnerab.
qr'.\.(mim|b64|bhx|hqx|xxe|uu|uue)$'i,
);
That will take care of exe files, screensavers, javascript, vbsciprt and wscript and a lot of other files you don't really want arriving in you users mailboxes. If not already set you can then specify
$final_banned_destiny = D_DISCARD;
which will discard the mails. And if you want to receive a copy to some admin mailadress, you can also define
$banned_quarantine_to = 'your admin mailadress here';
To handle other attachment types, like office (word, excel) documents, use the sanesecurity signatures. In most cases these signatures will recognize rouge malware within a couple of hours of the apearing.
The easiest way to set up these and some other signatures is to use clamav-unofficial-sigs which you can find at github:
https://github.com/extremeshok/clamav-unofficial-sigs
Once you've got eXtremeSHOK's script up and running it will keep your signatures updated and clamav (which is already being used by amavis) will scan your incomming and outgoing mail with the aditional signatures.
Hope this helps you some
Regards
Philip