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Topic: Mail between two domain

Hi
Can we have email between  Microsoft Exchange(X organization) and iredmail (y organization) via site to site VPN Tunnel. Should there be any type of changes at our mail server so that mail flow between two domains be a local setup.
Any suggestion is really helpful.

Regards
Philip

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Spider Email Archiver: On-Premises, lightweight email archiving software developed by iRedMail team. Supports Amazon S3 compatible storage and custom branding.